Plasma metabolic profiling analysis of Strychnos nux-vomica Linn. and Tripterygium wilfordii Hook F-induced renal toxicity using metabolomics coupled with UPLC/Q-TOF-MS
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چکیده
منابع مشابه
Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
BACKGROUND Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. OBJECTIVE The present study was aime...
متن کاملA short review on anticancer investigations of Strychnos nux-vomica
Herbs used in traditional medicine have provided a nidus for the discovery of various new molecules having therapeutic viability. With the advent of various diseases, the science has also armed itself to combat the everevolving family of diseases with the help of these new molecules. Cancer is one such area which has limited scope for management through conventional therapy. Recent research adv...
متن کاملSafety Profiles of Tripterygium wilfordii Hook F: A Systematic Review and Meta-Analysis
Objective:Tripterygium wilfordii Hook F (TwHF) is a widely used and effective treatment for inflammatory diseases. There have been concerns about its toxicity but no adequate synthesis of the evidence for adverse events (AEs). We aimed to undertake a clinically informative, systematic safety profile of TwHF. Methods: We undertook a systematic review and meta-analysis of experimental studies and...
متن کاملCorrigendum: Safety Profiles of Tripterygium wilfordii Hook F: A Systematic Review and Meta-Analysis
[This corrects the article on p. 402 in vol. 7, PMID: 27877128.].
متن کاملMale Germ Cell Apoptosis and Epigenetic Histone Modification Induced by Tripterygium wilfordii Hook F
Multiglycosides of Tripterygium wilfordii Hook f (GTW), a Chinese herb-derived medicine used as a remedy for rheumatoid arthritis, are considered to be a reversible anti-fertility drug affecting the mammalian spermatids. However, the mechanism behind this effect is still unknown. To study the possible mechanism behind the impact of GTW on spermatogenesis, we administered 4 groups of 4-week-old ...
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ژورنال
عنوان ژورنال: Toxicology Research
سال: 2018
ISSN: 2045-452X,2045-4538
DOI: 10.1039/c8tx00115d